HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1075457Generated: November 1, 2026
Water → N-(3-(3-Pyridyl)phenyl)-2-nitro-4-(1-pyrrolyl)aniline
https://huagongshe.com/reaction/1075457
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(Pyridin-3-yl)aniline | HCID 459521 | — |
| Reactant | 2-Nitro-4-(1-pyrrolyl)fluorobenzene | HCID 54102186 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-(3-(3-Pyridyl)phenyl)-2-nitro-4-(1-pyrrolyl)aniline | HCID 54302123 | — |
Reaction Steps
A mixture of 1a (0.5g, 2.4mmol) and 2a (0.41g, 2.4mmol) in N-methyl-2-pyrrolidone (2.5ml) is heated to 120-135° C. for 2 days. After cooling water and diluted sodium hydroxide is added and the mixture is extracted with ethyl acetate. The extract is dried over sodium sulfate, and the solvent is evaporated to leave crude 3a. This crude product is purified by column-chromatography on silica gel using dichloromethane and subsequently a mixture of dichloromethane and methanol (9:1) as the eluents to yield pure 3a (0.61g, 71%) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05902813 |
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| Source dataset | uspto-grants-1999_05 |
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| ORD ID | ord-d4c1f3c7dba84c46b09e982af156c5dd |
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| Source note | uspto-grants-1999_05 |
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