(4-Carbamoyl-3-(2,6-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester → 3-(2,6-Difluoro-4-methyl-benzyloxy)-5-[3-(4-hydroxy-5-piperidin-1-yl-pentyl)-ureido]-isothiazole-4-carboxylic acid amide
Reaction equation
[NH2:30][CH2:31][CH2:32][CH2:33][CH:34]([CH2:35][N:36]1[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]1)[OH:42].[c:1]1([O:2][C:8]([NH:9][c:10]2[c:11]([C:26]([NH2:27])=[O:28])[c:12]([O:15][CH2:16][c:17]3[c:18]([F:25])[cH:19][c:20]([CH3:24])[cH:21][c:22]3[F:23])[n:13][s:14]2)=[O:29])[cH:3][cH:4][cH:5][cH:6][cH:7]1>>[C:8]([NH:9][c:10]1[c:11]([C:26]([NH2:27])=[O:28])[c:12]([O:15][CH2:16][c:17]2[c:18]([F:25])[cH:19][c:20]([CH3:24])[cH:21][c:22]2[F:23])[n:13][s:14]1)(=[O:29])[NH:30][CH2:31][CH2:32][CH2:33][CH:34]([CH2:35][N:36]1[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]1)[OH:42]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-15e657e33e57444992cadc1750cc4fed
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
Loading…