Carbamic acid, N-methyl-, 4-nitrophenyl ester → 9-[(3-methylureido)methyl]-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Reaktionsgleichung
[NH2:1][CH2:2][C:3]1[C:4]2[CH2:5][C:6]3[N:11]4[CH:12]=[CH:13][N:14]=[C:10]4[C:9](=[O:15])[NH:8][C:7]=3[C:16]=2[CH:17]=[CH:18][CH:19]=1.[CH3:20][NH:21][C:22](=O)[O:23]C1C=CC([N+]([O-])=O)=CC=1>CN(C)C=O>[CH3:20][NH:21][C:22](=[O:23])[NH:1][CH2:2][C:3]1[C:4]2[CH2:5][C:6]3[N:11]4[CH:12]=[CH:13][N:14]=[C:10]4[C:9](=[O:15])[NH:8][C:7]=3[C:16]=2[CH:17]=[CH:18][CH:19]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 20 °C
Versuchsvorschrift
A suspension of 0.25 g of 9-aminomethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one, 0.49 g of 4-nitrophenyl N-methylcarbamate and 10 ml of dimethylformamide under an argon atmosphere is stirred for 4 hours at a temperature in the region of 20° C. The reaction mixture is filtered, washed successively with 5 ml of dimethylformamide and two times 20 ml of methyl-tert-butyl ether and then dried under reduced pressure (1 mm Hg; 0.13 kPa) at 60° C. 0.2 g of 9-[(3-methylureido)methyl]-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one is obtained in the form of a white solid, the melting point of which is greater than 260° C. (Analysis C16H15N5O2; % Calculated C: 62.13, H: 4.89, N: 22.64; % Found C: 62.03, H: 4.90, N: 22.26).
Aufarbeitung
- filtrationThe reaction mixture is filtered
- washwashed successively with 5 ml of dimethylformamide and two times 20 ml of methyl-tert-butyl ether
- customdried under reduced pressure (1 mm Hg; 0.13 kPa) at 60° C
Quellen und Nachweise
- ORD-Eintrag
- ord-fe2d818676c94675824192861bdc3592
- Quelldatensatz
- uspto-grants-1999_05
- Patentnummer
- US05902803
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