2-Thiophenecarboxaldehyde → HCID 9927370, compound

HRID 1075568Notes

Reaction equation

HRID 1075568 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[S:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[CH:23]=O>>[S:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[CH2:23][NH:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 73642-ThiophenecarboxaldehydeHCID 102202303-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine

Product 1

HCID 9927370HCID 9927370, compound

Procedure

Beginning with 0.25 gm (1.09 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.20 mL (2.17 mMol) thiophene-2-carboxaldehyde, the title compound was prepared essentially as described in Example 2.

Sources & evidence

ORD record
ord-03fd439e9e7c48f08f1a4927eaf3dab5
Source dataset
uspto-grants-1999_05
Patent number
US05905084

Reaction notes

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