Aspirin → Benzamide, 2-hydroxy-N-[3-(trifluoromethyl)phenyl]-

HRID 1075582Notes

Reaction equation

HRID 1075582 reaction equation
C([O:4][C:5]1[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:7]([OH:9])=O)(=O)C.[F:14][C:15]([F:24])([F:23])[C:16]1[CH:17]=[C:18]([CH:20]=[CH:21][CH:22]=1)[NH2:19]>>[F:14][C:15]([F:23])([F:24])[C:16]1[CH:17]=[C:18]([NH:19][C:7](=[O:9])[C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[OH:4])[CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 2244AspirinHCID 73753-(Trifluoromethyl)aniline

Product 1

HCID 68519Benzamide, 2-hydroxy-N-[3-(trifluoromethyl)phenyl]-

Procedure

This compound was obtained as a white solid starting from acetylsalicyclic acid and 3trifluoromethylaniline using the same procedure described in example 5.

Workup

  1. customThis compound was obtained as a white solid

Sources & evidence

ORD record
ord-0557723724024dacb96304134ccce0f8
Source dataset
uspto-grants-1999_05
Patent number
US05905090

Reaction notes

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