Hydrochloric Acid → HCID 18410269, compound

Participants

Reaction Steps

To a solution of 318 mg (5.8 mmol) of ethyl 2,6-dimethyl-4-fluoro-phenoxyacetate in 50 mL of methanol was added 1 mL of 3N sodium hydroxide. After the reaction mixture was stirred at room temperature for 30 min, it was acidified with 3N HCl to pH=4 and partitioned between water and methylene chloride. The combined organic extracts were washed with brine and dried over anhydrous sodium sulfate, filtered and evaporated to dryness under reduced pressure to give 248 mg (90%) of 2,6-dimethyl-4-fluoro-phenoxy acetic acid as a white solid.

Provenance & Evidence