反应详情

A solution of bromine (2.9 ml, 56.5 mmol) in 30 ml of CH2Cl2 was added dropwise to a solution of 2-acetyl-5-bromothiophene (10 g, 49 mmol), dioxane (55 ml) and ethyl ether (55 ml). The stirring was continued for 1 h and then the reaction medium was poured into a water/ice mixture and extracted with ethyl ether. The organic phase was washed twice with water, dried over magnesium sulfate and concentrated in a rotary evaporator under vacuum.

1. extractionextracted with ethyl ether
2. washThe organic phase was washed twice with water
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated in a rotary evaporator under vacuum