反应详情

温度

52.5 °C

Mix 5-hydroxymethyl-2-phenyl-1H-imidazole (1.3 Kg) and toluene (10.4 L) at 20-25° C., and then heat the mixture with stirring to 50-55° C. Add acetic anhydride (780 ml, 1.1 equivalents) slowly and continue heating at 50-55° C. until the reaction is complete (typically 3-4 hours). Cool the reaction mixture to -5-0° C., filter off the product, wash it with toluene (3×700 ml) and then dry it under vacuum at 50-55° C. to constant weight.

1. temperatureheat the mixture
2. customtypically 3-4 hours
3. temperatureCool the reaction mixture to -5-0° C.
4. filtrationfilter off the product
5. washwash it with toluene (3×700 ml)
6. customdry it under vacuum at 50-55° C. to constant weight