Sodium Hydroxide → HCID 131721268, compound

HRID 1075666Notes

Reaction equation

HRID 1075666 reaction equation
C([O:3][C:4](=[O:29])[CH:5]([O:7][C:8]1[CH:9]=[CH:10][C:11]([CH:18]=[C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[NH:21][C:20]2=[O:28])=[C:12]2[C:17]=1[N:16]=[CH:15][CH:14]=[CH:13]2)[CH3:6])C.[OH-].[Na+:31]>O1CCOCC1>[Na+:31].[NH:21]1[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:19](=[CH:18][C:11]2[CH:10]=[CH:9][C:8]([O:7][CH:5]([CH3:6])[C:4]([O-:29])=[O:3])=[C:17]3[C:12]=2[CH:13]=[CH:14][CH:15]=[N:16]3)[C:20]1=[O:28]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69726085HCID 69726085, compound

Product 1

HCID 131721268HCID 131721268, compoundYield 73.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a suspension of 2-[5-(2-oxindol-3-ylidenemethyl)quinol-8-yloxy]propionic acid ethyl ester (150 mg, 0.39 mmol) in dioxane (15 ml) was added dropwise 2N sodium hydroxide (1.0 ml, 2 mmol) and the reaction mixture was stirred for another 1 h at room temperature. The crystalline precipitate was filtered and dried to give pure title compound in 73.8% yield (110 mg).

Workup

  1. filtrationThe crystalline precipitate was filtered
  2. customdried

Sources & evidence

ORD record
ord-5e060b5ad9cd4d50896d31499ecc72aa
Source dataset
uspto-grants-1999_05
Patent number
US05905149

Reaction notes

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