Sodium Hydroxide → HCID 131721269, compound

Participants

Reaction Steps

To a solution of N-{2-[5-(2-oxindol-3-ylidenemethyl)quinol-8-yloxy]propionyl} alanine methyl ester (50 mg, 0.11 mmol) in THF (10 ml) was added dropwise 2N sodium hydroxide (0.1 ml) at 0-50° C. After 4h stirring at room temperature THF (100 ml) was added, the organic layer washed 3 times with saturated sodium chloride solution, dried over magnesium sulfate and concentrated under vacuum. The residue was taken up in 5% sodium bicarbonate (10 ml) and chromatographed on a LoBar RP18 column using as eluant water/methanol (7:3) to give pure title compound in 84-yield (42 mg).

Provenance & Evidence