Triethylamine → HCID 67619232, compound

Participants

Reaction Steps

To a solution of 2-[3-(8-benzyloxyquinol-5-ylmethylen)-2-oxindol-1-yl] acetic acid sodium salt (50 mg, 0.11 mmol), benzotriazol-1-yloxytrispyrrolidinophosphonium hexafluorophosphate (50 mg, 0.10 mmol) and triethylamine (11 mg, 0.11 mmol) in dichloromethane (10 ml) was added L-alanine methyl ester hydrochloride (20 mg, 0.14 mmol) and the mixture was stirred for 2 h at room temperature. Then dichloromethane was added, the organic layer washed 3 times with water, dried over sodium sulfate and concentrated under vacuum. The residue was chromatographed on silica gel using as eluant ethylacetate/cyclohexane (8:2) to give 45 mg (78.5% yield) of title compound.

Provenance & Evidence