Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3,5-Xylyloxyacetic acid | HCID 79405 | — |
| Product | 4,6-Dimethyl-3(2H)-benzofuranone | HCID 595599 | 100% |
Reaction Steps
A mix of polyphosphoric acid and 2-(3,5-dimethylphenoxy) acetic acid was heated at 50° C. for 8 hours. The mix was poured in ice, treated with ammonia until a pH 7 was obtained. The mix was extracted with methylenechloride and the organic phase was treated with a solution of bicarbonate, made anhydrous (Na2SO4) and freed from the solvent under reduced pressure, to produce 4,6-dimethyl-3-benzofuranone (40% conversion, 100% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05907045 |
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| Source dataset | uspto-grants-1999_05 |
|---|
| ORD ID | ord-0b5106c9a29a4d089c707bfab336e0cd |
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| Source note | uspto-grants-1999_05 |
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