化工社化工社 化学情報印刷レポート · 研究参考用
Benzoic acid, 4,5-dimethoxy-2-nitro-, methyl ester → Methyl 4,5-dimethoxyanthranilate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoic acid, 4,5-dimethoxy-2-nitro-, methyl ester | HCID 117867 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Methyl 4,5-dimethoxyanthranilate | HCID 611144 | 97.5% |
反応手順
In an hydrogenating autoclave, there are placed 144 g of methyl 3,4-dimethoxy-6-nitro-benzoate, 300 ml of tetrahydrofuran and 3 coffee spoonfuls of Raney nickel. Hydrogenation occurs at about 35°C. In 20 minutes, the pressure drop is 80 kg. It is cooled, the nickel filtered, and the tetrahydrofuran removed under vacuum. There are obtained 123 g (97%) of methyl 3,4-dimethoxy-6-aminobenzoate. (m.p.: 130°C).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03954748 |
| 出典データセット | uspto-grants-1976_05 |
| ORD ID | ord-fabfc5445ebb48ad9ce453bdad101005 |
| 出典メモ | uspto-grants-1976_05 |