Phenothiazine → Ethyl 3-(diethylamino)propionate

Participants

Reaction Steps

The following materials were charged to the reaction vessel: anhydrous diethylamine (292 grams); ethyl acrylate (200 grams); phenothiazine (1.0 gram); and p-methoxyphenol (1.0 gram). This mixture was heated at reflux (about 56°-60°C.) for 24 hours. At the end of this period, unreacted amine was removed by distillation. The product was recovered at 80°-81°C. and 10 mm. mercury pressure in a yield of 96 percent. The product is designated herein as Amine Catalyst IX and has the formula, (C2H5)2N-CH2CH2 -C(O)OC2H5, as verified analytically by infrared spectroscopy.

Provenance & Evidence