Iodine → HCID 86733375, compound

Participants

Reaction Steps

A mixture of 3.2 g indole-2-carboxylic acid in 50 ml methanol and 2 g 2-imidazolidinethione in 100 ml methanol is added to a well-stirred solution of 3 g iodine and 25 g potassium iodide in 50 ml water. After being stirred for 2 hours at room temperature, the mixture is filtered to remove the product. The filtrate is concentrated and cooled to give further yield. The combined product is recrystallised from alcohol-ether to give 3-(2-imidazolin-2-ylthio)-indole-2-carboxylic acid hydriodide melting above 310°.

Provenance & Evidence