Indole → HCID 12934747, compound

Participants

Reaction Steps

A solution of 9.36 g of indole in 60 ml methanol is added dropwise to a well-stirred solution of 40 g potassium iodide and 20.3 g of iodine in 120 ml of water at room temperature. This is reacted with a solution of 10.6 g of 2-mercapto-1,4,5,6-tetrahydro-5-pyrimidinol in 1800 ml of 50% aqueous methanol. The reaction mixture is stirred at room temperature for 2 hours and worked up in the manner, described under Example 1 to yield 3-(5-hydroxy-1,4,5,6-tetrahydro-2-pyrimidinylthio)-indole hydriodide which melts at 228°-229° (with decomposition) after recrystallization from a mixture of methanol, ethyl acetate and ether.

Provenance & Evidence