Iodine → HCID 12934723, compound

Participants

Reaction Steps

A solution of 5.7 g of 5-methoxy-indole-2-carboxylic acid in 70 ml of hot methanol is added portionwise to a solution of 15 g potassium iodide and 7.6 g of iodine in 45 ml of water. This is further treated with a solution of 3.48 g of 1,4,5,6-tetrahydro-2-pyrimidinethiol in 70 ml of hot methanol, stirred at room temperature for 2 hours and filtered. The filtrate is worked up in the manner described under Example 1 to yield 5-methoxy-3-(1,4,5,6-tetrahydro-2-pyrimidinylthio)-indole-2-carboxylic acid hydriodide which melts at 239°-240° after recrystallization from a mixture of methanol, ethyl acetate and ether.

Provenance & Evidence