Iodine → HCID 12934733, compound

Participants

Reaction Steps

A solution of 3.45 g of 5-methoxy-indole-2-carboxylic acid in 50 ml methanol is added to a solution of 4.57 g of iodine and 9 g of potassium iodide in 27 ml of water. This is treated with a solution of 2.34 g of 1-methyl-1,4,5,6-tetrahydro-2-pyrimidinethiol in 30 ml of water. The reaction is carried out and worked up as described under Example 1 to yield 5-methoxy-3-(1-methyl-1,4,5,6-tetrahydro-2-pyrimidinylthio)-indole-2-carboxylic acid hydriodide which melts at 256° (with decomposition) after recrystallization from a mixture of methanol and ethyl acetate.

Provenance & Evidence