Iodine → HCID 12934729, compound

Participants

Reaction Steps

A solution of 12.7 g of iodine and 20 g of potassium iodide in 100 ml water is added dropwise to a mixture of 7.25 g of 1,2-dimethylindole in 30 ml of methanol and 5.8 g of 1,4,5,6-tetrahydro-2-pyrimidinethiol in 120 ml of warm methanol. The reaction mixture is stirred for 2 hours at room temperature. The crystalline precipitate formed was filtered and recrystallized from a mixture of methanol and ethyl acetate to yield 1,2-dimethyl-3-(1,4,5,6-tetrahydro-2-pyrimidinylthio)-indole hydriodide which melts at 246° (with decomposition).

Provenance & Evidence