Sulfuric Acid → N-methyl-2H-3-isoquinolone

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Reaction Steps

A solution of 80 g. N-formyl-N-methyl-2-phenyl-acetamide in 200 ml. concentrated sulfuric acid is left to stand for 12 hours at ambient temperature in an atmosphere of nitrogen. This solution is then poured, while stirring, into 1 liter ethanol and cooled in an ice bath in order to maintain the temperature at about 20°-30°C. The crystalline product obtained is filtered off and washed with cold ethanol and dried. There are obtained 70 g. N-methyl-2H-3-isoquinolone sulfate, which has a melting point of 235°-236°C.; yield 60% of theory. The analysis shows that it is a compound of the empirical formula C10H9NO.H2SO4 :

Provenance & Evidence