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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1075836Generated: October 31, 2026

1-(3-Chlorophenyl)piperazine → 6-[p-[4-(m-Chlorophenyl)-1-piperazinyl]phenyl]-1,2-dihydro-2-oxonicotinonitrile

https://huagongshe.com/reaction/1075836

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3-Chlorophenyl)piperazineHCID 1355—
Reactant6-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrileHCID 2765203—
SolventDimethyl SulfoxideHCID 679—
Product6-[p-[4-(m-Chlorophenyl)-1-piperazinyl]phenyl]-1,2-dihydro-2-oxonicotinonitrileHCID 21404505—

Reaction Steps

From 12.9 g. of 6-(p-fluorophenyl)-1,2-dihydro-2-oxonicotinonitrile and 23.7 g. of N-(m-chlorophenyl)-piperazine in 180 ml. of dimethyl sulfoxide; there is obtained 6-[p-[4-(m-chlorophenyl)-1-piperazinyl]phenyl]-1,2-dihydro-2-oxonicotinonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03954734
Source datasetuspto-grants-1976_05
ORD IDord-ccfc903ef03942eeb8a5a99459a9ec31
Source noteuspto-grants-1976_05