Nanofin → HCID 21541283, compound

HRID 1075850Notes

Reaction equation

HRID 1075850 reaction equation
[O:1]1[CH:3]([CH2:4][O:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[O:12][CH2:13][CH2:14][O:15][CH3:16])[CH2:2]1.[CH3:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH:20]([CH3:24])[NH:19]1>O.CO>[CH3:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH:20]([CH3:24])[N:19]1[CH2:2][CH:3]([OH:1])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH2:13][CH2:14][O:15][CH3:16]

Participants

5

Reactant 2

HCID 68843NanofinHCID 136824262-{[2-(2-Methoxyethoxy)phenoxy]methyl}oxirane

Product 1

HCID 21541283HCID 21541283, compoundYield 76.8%

Reagents, catalysts & solvents 2

HCID 962WaterCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4.5 g of 1,2-epoxy-3-[2-(2-methoxyethoxy)phenoxy]-propane, 2.4 g of 2,6-dimethylpiperidine, 30 ml of methanol and 1 drop of water is refluxed for 8 hours. The methanol is then removed, and the residue is cooled. The precipitated colorless crystals are collected by filtration, and washed with petroleum benzine to give 5.2 g of 1-(2,6-dimethylpiperidino)-3-[2-(2-methoxyethoxy)phenoxy]-2-propanol, melting at 92°-94°C.

Workup

  1. temperatureis refluxed for 8 hours
  2. customThe methanol is then removed
  3. temperaturethe residue is cooled
  4. filtrationThe precipitated colorless crystals are collected by filtration
  5. washwashed with petroleum benzine

Sources & evidence

ORD record
ord-3a2ec45a3f4448c1ad9650d647b2ff42
Source dataset
uspto-grants-1976_05
Patent number
US03954776

Reaction notes

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