1-Piperazinecarboxylic acid, ethyl ester → HCID 21416190, compound

HRID 1075867Notes

Reaction equation

HRID 1075867 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[S:6][C:7]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:8]=3[CH:9](Cl)[CH2:10][C:4]=2[CH:3]=1.[C:19]([N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)([O:21][CH2:22][CH3:23])=[O:20]>C(Cl)(Cl)Cl>[C:19]([N:24]1[CH2:29][CH2:28][N:27]([CH:9]2[C:8]3[CH:12]=[C:13]([F:16])[CH:14]=[CH:15][C:7]=3[S:6][C:5]3[CH:17]=[CH:18][C:2]([Cl:1])=[CH:3][C:4]=3[CH2:10]2)[CH2:26][CH2:25]1)([O:21][CH2:22][CH3:23])=[O:20]

Participants

4

Reactant 2

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 12232370HCID 12232370, compound

Product 1

HCID 21416190HCID 21416190, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

24 G. of 2,10-dichloro-8-fluoro-10,11-dihydro-dibenzo[b,f]thiepin in 80 ml. of chloroform are heated together with 38.4 g. of 1-carbethoxy-piperazine under reflux conditions for 20 hours. The reaction mixture is poured over ice water and extracted with chloroform. The organic phase is dried over magnesium sulfate and evaporated under reduced pressure, whereby there is obtained oily 1-carbethoxy-4-(2-chloro-8-fluoro-10,11-dihydro-dibenzo [b,f]thiepin-10-yl)-piperazine.

Workup

  1. extractionextracted with chloroform
  2. dry with materialThe organic phase is dried over magnesium sulfate
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-65cd238713c445648f05f4ffcbccf6f4
Source dataset
uspto-grants-1976_05
Patent number
US03954764

Reaction notes

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