2-tert-Butylbenzoyl chloride → HCID 12582674, compound

HRID 1075904Notes

Reaction equation

HRID 1075904 reaction equation
[C:1]([C:5]1[CH:23]=[CH:22][C:8]([C:9]([N:11]2[CH2:21][CH2:20][C:14]3[N:15]=[N:16][C:17](Cl)=[CH:18][C:13]=3[CH2:12]2)=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(O)(=O)/C=C\C(O)=O.ClC1[N:38]=[N:37]C2CCNCC=2C=1.C(C1C=CC=CC=1C(Cl)=O)(C)(C)C>C(O)C>[C:1]([C:5]1[CH:23]=[CH:22][C:8]([C:9]([N:11]2[CH2:21][CH2:20][C:14]3[N:15]=[N:16][C:17]([NH:37][NH2:38])=[CH:18][C:13]=3[CH2:12]2)=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 137671862-tert-Butylbenzoyl chlorideHCID 20441624HCID 20441624, compoundHCID 86733381HCID 86733381, compound

Product 1

HCID 12582674HCID 12582674, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The 6-(p-tert.butylbenzoyl)-3-chloro-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine, required as starting material, may be obtained in a manner analogous to that described in Example 8 (g), from 34.2 g of 3-chloro-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine maleate and 25 g of tert.butylbenzoyl chloride. M.P. 157°-160° (decomp., from 95% ethanol).

Workup

  1. custommay be obtained in a manner analogous to

Sources & evidence

ORD record
ord-842ab296759d4a679f6e977da9a03c6c
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

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