HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dihydroxybenzoic acid → 3-Hydrazino-5,6,7,8-tetrahydro-6-(4-phenylbutyryl)pyrido[4,3-c]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dihydroxybenzoic acid | HCID 3469 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 3-Chloro-5,6,7,8-tetrahydro-6-(4-phenylbutyryl)pyrido[4,3-c]pyridazine | HCID 20441567 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Hydrazino-5,6,7,8-tetrahydro-6-(4-phenylbutyryl)pyrido[4,3-c]pyridazine | HCID 12582697 | — |
Reaction Steps
11.8 g of 3-chloro-5,6,7,8-tetrahydro-6-(4-phenylbutyryl)pyrido[4,3-c]pyridazine and 60 cc of hydrazine hydrate are stirred at a bath temperature of 50° for 53 hours with the addition of 50 cc of dioxane. The mixture is worked up as described in Example 10. The gentisinate of the title compound has a M.P. of 203°-205° (decomp., from methanol/water 2:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03954754 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-06f60652871948b19fd5ebf238bbf34e |
| Source note | uspto-grants-1976_05 |