2-Propylvaleryl chloride → HCID 12582648, compound

HRID 1075919Notes

Reaction equation

HRID 1075919 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([C:12](=[O:20])[CH:13]([CH2:17][CH2:18][CH3:19])[CH2:14][CH2:15][CH3:16])[CH2:11][C:4]=2[CH:3]=1.C(O)(=O)/C=C\C(O)=O.ClC1[N:35]=[N:34]C2CCNCC=2C=1.C(C(CCC)C(Cl)=O)CC>>[NH:34]([C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([C:12](=[O:20])[CH:13]([CH2:17][CH2:18][CH3:19])[CH2:14][CH2:15][CH3:16])[CH2:11][C:4]=2[CH:3]=1)[NH2:35]

Participants

4

Reactant 3

HCID 762402-Propylvaleryl chlorideHCID 20441625HCID 20441625, compoundHCID 86733381HCID 86733381, compound

Product 1

HCID 12582648HCID 12582648, compound

Procedure

The 3-chloro-5,6,7,8-tetrahydro-6-(2-n-propylvaleroyl)pyrido[4,3-c]pyridazine, required as starting material, is produced in a manner analogous to that described in Example 8 (g), from 3-chloro-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine maleate and 2-n-propylvaleroyl chloride. The organic phase is concentrated, and the crude product is extracted from the resulting solid residue with a Soxhlet extraction apparatus, and is recrystallized from cyclohexane. M.P. 94°-95°.

Workup

  1. customis produced in a manner analogous to
  2. concentrationThe organic phase is concentrated
  3. extractionthe crude product is extracted from the resulting solid residue with a Soxhlet extraction apparatus
  4. customis recrystallized from cyclohexane

Sources & evidence

ORD record
ord-45a459dad0a34379ac66ec21687f1d71
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

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