Methylhydrazine → HCID 12582634, compound

HRID 1075922Notes

Reaction equation

HRID 1075922 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:16][CH2:15][C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:8]=2[CH2:7]1)=[O:5])[CH3:2].C(COC)OC.[CH3:23][NH:24][NH2:25]>>[CH2:1]([O:3][C:4]([N:6]1[CH2:16][CH2:15][C:9]2[N:10]=[N:11][C:12]([N:24]([CH3:23])[NH2:25])=[CH:13][C:8]=2[CH2:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 6061MethylhydrazineHCID 80711,2-DimethoxyethaneHCID 12582766Ethyl 3-chloro-7,8-dihydropyrido[4,3-c]pyridazine-6(5H)-carboxylate

Product 1

HCID 12582634HCID 12582634, compound

Procedure

72.6 g of 3-chloro-5,6,7,8-tetrahydro-6-pyrido[4,3-c]pyridazinecarboxylic acid ethyl ester are heated at reflux in 300 cc of methylhydrazine at a bath temperature of 110° for 1 hour while stirring, and the mixture is concentrated, the residue divided between chloroform and water and after concentrating the chloroform phase the title compound is obtained, M.P. 121°-123° (dec., from dimethoxyethane).

Workup

  1. concentrationthe mixture is concentrated
  2. concentrationafter concentrating the chloroform phase the title compound
  3. customis obtained

Sources & evidence

ORD record
ord-213e55bca59e44a58b345e1942a4926a
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

Loading…