HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → Endralazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Ethyl Bromide | HCID 6332 | — |
| Reactant | HCID 20441570 | HCID 20441570 | — |
| Reactant | HCID 178519528 | HCID 178519528 | — |
| Solvent | Diethyl ether 2-propanol | HCID 22147583 | — |
| Product | Endralazine | HCID 47608 | — |
Reaction Steps
The 3-ethylmercapto-6-benzoyl-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine, required as starting material, may be obtained in a manner analogous to that described in Example 41 (b), from 34.8 g of 6-benzoyl-3-mercapto-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine and 16.8 g of ethyl bromide. Reaction time 19 hours. Working up as described in Example 41 (b), eluant: benzene. M.P. 132°-135° (decomp., from isopropanol/ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03954754 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-a220a7de68a5407ab7eb71fd898b6978 |
| Source note | uspto-grants-1976_05 |