Acetone → HCID 12582658, compound

HRID 1075951Notes

Reaction equation

HRID 1075951 reaction equation
[C:1]([N:9]1[CH2:20][CH2:19][C:12]2[N:13]=[N:14][C:15]([NH:17][NH2:18])=[CH:16][C:11]=2[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:21][C:22]([CH3:24])=O>C(O)(=O)C>[C:1]([N:9]1[CH2:20][CH2:19][C:12]2[N:13]=[N:14][C:15]([NH:17][N:18]=[C:22]([CH3:24])[CH3:21])=[CH:16][C:11]=2[CH2:10]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 180AcetoneHCID 47608Endralazine

Product 1

HCID 12582658HCID 12582658, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidCatalyst

Procedure

A solution of 0.5 g of 6-benzoyl-3-hydrazino-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine in 15 cc of absolute acetone, to which 4 drops of glacial acetic acid have been added, is heated on a water bath for 1 hour. The solution is concentrated in a vacuum, and the crude title compound, obtained as an oil, is crystallized with ether. The title compound has a M.P. of 188°-190° (decomp.).

Workup

  1. temperatureis heated on a water bath for 1 hour
  2. concentrationThe solution is concentrated in a vacuum

Sources & evidence

ORD record
ord-00292f0469684d739e2bc8d1a090f814
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

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