Thiourea → HCID 178527708, compound

HRID 1075952Notes

Reaction equation

HRID 1075952 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:4]=2[CH:3]=1.NC(N)=[S:16]>C(O)C>[SH:16][C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 20441588HCID 20441588, compound

Product 1

HCID 178527708HCID 178527708, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

59.1 g of 3-chloro-5,6,7,8,9,10-hexahydrocycloocta[c]pyridazine and 25.2 g of thiourea are heated at reflux in 250 cc of absolute ethanol while stirring for 20 hours. The reaction mixture is subsequently concentrated and divided between chloroform and water. After concentrating the chloroform phase, crude 3-mercapto-5,6,7,8,9,10-hexahydrocycloocta[c]pyridazine is obtained and is recrystallized from 250 cc of absolute ethanol with the addition of carbon. M.P. 167°-170° (decomp.).

Workup

  1. concentrationThe reaction mixture is subsequently concentrated
  2. concentrationAfter concentrating the chloroform phase

Sources & evidence

ORD record
ord-33895937667a45b6ac34d5f555a62168
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

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