HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methylhydroxylamine hydrochloride → alpha-(1-Methyl-2-nitroimidazole-5-yl)-N-methylnitrone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methylhydroxylamine hydrochloride | HCID 77906 | — |
| Reactant | 1-Methyl-2-nitro-1H-imidazole-5-carboxaldehyde | HCID 100390 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | alpha-(1-Methyl-2-nitroimidazole-5-yl)-N-methylnitrone | HCID 325650 | — |
Reaction Steps
A mixture of 0.250 g. of 1-methyl-2-nitro-5-imidazolecarboxaldehyde, 0.150 g. of N-methylhydroxylamine hydrochloride and 0.150 g. of sodium bicarbonate is refluxed in 80 ml. of anhydrous ethanol for 2 hours and after filtration is concentrated to small volume. The title compound crystallizes on cooling. Yield: 0.24 g. m.p. 208° -209° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03954789 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-4b173e1c42574c94b393574ccd70786e |
| Source note | uspto-grants-1976_05 |