Ethylene Oxide → 4,5,6,7-Tetrabromo-1,3-dihydro-1,3-bis(2-hydroxyethyl)-2H-benzimidazol-2-one

Participants

Reaction Conditions

Reaction Steps

44.96 g (0.1 mol) of 4,5,6,7-tetrabromobenzimidazolone are stirred with 250 ml of dimethylacetamide and 2.5 g of lithium chloride. A solution of 13.2 g of ethylene oxide (0.3 mol) in 100 ml of dimethylacetamide is added to this mixture at room temperature. The mixture is stirred slowly and heated to 80°C over the course of 2.5 hours. It is then stirred for a further 2 hours at 100°C. During the course of the reaction the starting material dissolves completely.

Provenance & Evidence