1H-1,2,4-Triazole → 1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone

Participants

Reaction Steps

According to the Spanish Patent Number ES 549 020 A1 1 mole of 1,3-dichloroacetone is reacted with 2 mole of 1,2,4-triazole, then the 1,3-bis(1,2,4-triazole-1-yl)-propan-2-on obtained with low yield is reacted with 2,4-difluorophenylmagnesium bromide to give fluconazole. The yield is about 45% calculated on the Grignard reagent.

Provenance & Evidence