Isopropylamine → HCID 21541773, compound

Participants

Reaction Steps

To 5.7 g of 3-methyl-4-methylthiophenylethylene oxide in 30 cc of isopropanol, 7.6 g of isopropylamine are added. The solution is refluxed overnight. The solvent and excess of amine are evaporated under vacuum. The oil obtained crystallises a little moment later. 12.1 g of 1-(3-methyl-4-methylthiophenyl)-2-isopropylaminoethanol are obtained (yield of 61 %) which are recrystallised from cyclohexane. Melting point: 89.5°-90.5°. The hydrochloride is recrystallised from a methanol-ether mixture; melting point: 154°-155.5°C.

Provenance & Evidence