Propionic Acid → HCID 178437979, compound

HRID 1076117Notes

Reaction equation

HRID 1076117 reaction equation
[NH2:1][NH:2][C:3]([NH:5][NH2:6])=[S:4].[C:7](O)(=O)[CH2:8][CH3:9]>CCOCC>[NH2:1][N:2]1[C:7]([CH2:8][CH3:9])=[N:6][N:5]=[C:3]1[SH:4]

Participants

4

Reactant 2

HCID 1032Propionic AcidHCID 2724189Thiocarbohydrazide

Product 1

HCID 178437979HCID 178437979, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Thiocarbohydrazide, 212.2 grams, is added to 500 ml. of propionic acid and heated to its reflux temperature for approximately 90 minutes. The reaction mixture is cooled to room temperature and diluted with anhydrous ether. After standing overnight in the refrigerator, the desired 4-amino-5-ethyl-4H-1,2,4-triazole-3 -thiol is filtered, washed with anhydrous ether and air dried to yield a product having a m.p. of 143°-6° C.

Workup

  1. temperaturereflux temperature for approximately 90 minutes
  2. filtrationthe desired 4-amino-5-ethyl-4H-1,2,4-triazole-3 -thiol is filtered
  3. washwashed with anhydrous ether and air
  4. customdried
  5. customto yield a product

Sources & evidence

ORD record
ord-0a85481d396c4c4d83c3b8f6ab60f468
Source dataset
uspto-grants-1976_05
Patent number
US03954983

Reaction notes

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