HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isothiocyanate → N-methyl-N'-(4-(2-pyridyl)butyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 4-(Pyridin-2-yl)butan-1-amine | HCID 13511083 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-methyl-N'-(4-(2-pyridyl)butyl)thiourea | HCID 20466716 | 67.3% |
Reaction Steps
The reaction of 2-(4-aminobutyl)pyridine (3.0 g) and methyl isothiocyanate (1.6g) in ethanol (25 ml) for 0.5 hours followed by chromatography of the product on silica and elution with ethyl acetate affords N-methyl-N'-(4-(2-pyridyl)butyl)thiourea (3.0 g) as a colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03954982 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-877e2e5f4dc947ddbd47e165f5fa26bc |
| Source note | uspto-grants-1976_05 |