反应详情

A solution of 4-methyl-5-(2-aminoethyl thiomethyl)imidazole (1.7 g.) and S-methyl-N-nitroisothiourea (1.45 g.) in methanol (35 ml.) was heated at 50°-60° for 2.5 hours and then set aside at room temperature for 48 hours. The crystalline product was filtered off and recrystallised from methanol to give N-(2-[(4-methyl-5-imidazolyl) methylthio]ethyl)-N'-nitroguanidine, m.p. 184°-186°.

1. filtrationThe crystalline product was filtered off
2. customrecrystallised from methanol