1-Butanol → HCID 6604391, compound

Participants

Reaction Steps

To an efficiently stirred mixture of water (250 ml) containing sodium bicarbonate (10 g) and hexane (250 ml, boiling range 60°-80° C), n-butanol (15 ml) and crystalline seed (1 g) were added. Pivampicillin hydrochloride (50 g) dissolved in water (200 ml) was introduced over 1 hour at room temperature. The mixture was filtered and the residue washed with isopropanol-water (1:4) (250 ml), isopropanol (150 ml) and hexane (300 ml, bp. 60°-80° C). Air-drying at 25° C overnight yielded crystalline pivampicillin with a melting point of 114° C.

Provenance & Evidence