Methyl Isocyanate → HCID 21539426, compound

Participants

Reaction Steps

A solution of 5 g 2-amino-3-cyano-4-sec-butylthiophene and 10 ml methyl isocyanate in 20 ml dimethoxyethane was stirred at about 25°C. for 2 days and then at reflux for 6 hours. The reaction mixture was evaporated under reduced pressure and the residue was chromatographed on a silica-gel column. The product, a white solid melting at 149°-152°C., was eluted with 70% ether-30% hexane. The infrared spectrum of the product showed cyano absorption at 4.5 microns. Sulfur analysis for the product is tabulated in Table I.

Provenance & Evidence