Methyl Isocyanate → HCID 21539419, compound

Participants

Reaction Steps

A solution of 10 g 2-amino-3-cyano-4-cyclopropylthiophene, 6.94 g methyl isocyanate and 0.1 g dibutyl tin dilaurate in 20 ml dimethoxyethane was refluxed for 7 hours and then allowed to stand at about 25°C. overnight. The reaction mixture was evaporated and the resulting residue was chromatographed on silica gel. The product, a pale-green solid melting at 169°-172°C., was eluted with 1:1 ether-hexane. Sulfur analysis for the product is tabulated in Table I.

Provenance & Evidence