Formic Acid → 3,9-dimethyl-2-hydroxymethyl-9H-dibenzo [b,f]-imidazo[1,2-d][1,4]diazepine

HRID 1076212Notes

Reaction equation

HRID 1076212 reaction equation
[CH3:1][C:2]1[N:6]2[C:7]3[CH:19]=[CH:18][CH:17]=[CH:16][C:8]=3[NH:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[C:5]2=[N:4][CH:3]=1.[CH2:20]=O.[CH:22]([OH:24])=O>>[CH3:1][C:2]1[N:6]2[C:7]3[CH:19]=[CH:18][CH:17]=[CH:16][C:8]=3[N:9]([CH3:20])[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[C:5]2=[N:4][C:3]=1[CH2:22][OH:24]

Participants

4

Reactant 3

HCID 284Formic AcidHCID 712FormaldehydeHCID 30466853-methyl-9H-dibenzo[b,f]imidazo[1,2-d][1,4]diazepine

Product 1

HCID 536579033,9-dimethyl-2-hydroxymethyl-9H-dibenzo [b,f]-imidazo[1,2-d][1,4]diazepine

Procedure

3-methyl-9H-dibenzo[b,f]imidazo[1,2-d][1,4]diazepine is dissolved in 88% formic acid, treated with 37% aqueous formalin solution and heated for 24 hours, to give 3,9-dimethyl-2-hydroxymethyl-9H-dibenzo [b,f]-imidazo[1,2-d][1,4]diazepine.

Workup

  1. temperatureheated for 24 hours

Sources & evidence

ORD record
ord-f3d0e9ce5d1e4911af6441ea5c5348a6
Source dataset
uspto-grants-1976_05
Patent number
US03956297

Reaction notes

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