HCID 21539380, compound → HCID 21539400, compound

HRID 1076233Notes

Reaction equation

HRID 1076233 reaction equation
[CH3:1][CH:2]1[CH:6]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=2)[CH2:5][NH:4][C:3]1=[O:16]>C(O)C.[H][H].[Ni]>[NH2:13][C:10]1[CH:9]=[CH:8][C:7]([CH:6]2[CH2:5][NH:4][C:3](=[O:16])[CH:2]2[CH3:1])=[CH:12][CH:11]=1

Participants

5

Reactant 1

HCID 21539380HCID 21539380, compound

Product 1

HCID 21539400HCID 21539400, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 702EthanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

45 g. of the 3-methyl-4-p-nitrophenyl-2-pyrrolidinone prepared in Example 5 are dissolved in 3 liters of absolute ethanol and hydrogenated at 100°C. with hydrogen at a pressure of 90 kg./cm.2, in the presence of 5 g. of Raney nickel as catalyst. When the hydrogen absorption has finished, the catalyst is filtered off and the filtrate is evaporated to dryness. The residue is recrystallized twice from ethanol. 30 g. of 4-p-aminophenyl-3-methyl-2-pyrrolidinone are obtained. M.P. : 190°-194°C.

Workup

  1. customWhen the hydrogen absorption
  2. filtrationthe catalyst is filtered off
  3. customthe filtrate is evaporated to dryness
  4. customThe residue is recrystallized twice from ethanol

Sources & evidence

ORD record
ord-5cf079adf4914753806a620b922541f3
Source dataset
uspto-grants-1976_05
Patent number
US03956314

Reaction notes

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