Diethyl Malonate → HCID 54403188, compound

Participants

Reaction Steps

The 3-carboxy-4-p-chlorophenyl-5-phenyl-2-pyrrolidinone (after recrystallization from ethanol M.P. : 184°C. (decomposition)) was prepared by condensing 1-p-chlorophenyl-2-nitro-2-phenyl-ethylene with the sodium derivative of diethyl malonate, reduction of the obtained ethyl 2-carbethoxy-3-p-chlorophenyl-4-nitro-4-phenyl-butanoate (M.P. : 148°-149°C. (recrystallized from ethanol) by means of hydrogen under pressure in presence of Raney cobalt and hydrolysis of the resulting 3-carbethoxy-4-p-chlorophenyl-5-phenyl-2-pyrrolidinone (M.P. : 198°C. (recrystallized from toluene)).

Provenance & Evidence