Water → HCID 21539485, compound

HRID 1076240Notes

Reaction equation

HRID 1076240 reaction equation
[CH3:1][N:2]1[CH2:7][C:6]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[C:5](=O)[NH:4][CH2:3]1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:22].O>C1C=CC=CC=1>[CH3:1][N:2]1[CH2:7][C:6]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[C:5](=[S:22])[NH:4][CH2:3]1

Participants

5

Reactant 3

HCID 962WaterHCID 14817Phosphorus sulfide (P2S5)HCID 215395001,2,3,6-tetrahydro-1-methyl-5-phenyl-5-(2-pyridyl)-4(5H)-pyrimidinone

Product 1

HCID 21539485HCID 21539485, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 1,2,3,6-tetrahydro-1-methyl-5-phenyl-5-(2-pyridyl)-4(5H)-pyrimidinone in benzene is added 0.16 equivalent of phosphorus pentasulfide. The reaction mixture is heated gently for 30 minutes then water is added and the layers are separated. The aqueous layer is extracted again with benzene and the organic layers are combined, washed with water, dried (MgSO4) and concentrated in vacuo to give 1,2,3,6-tetrahydro-1-methyl-5-phenyl-5-(2-pyridyl)-4(5H)-pyrimidinethione.

Workup

  1. temperatureThe reaction mixture is heated gently for 30 minutes
  2. customthe layers are separated
  3. extractionThe aqueous layer is extracted again with benzene
  4. washwashed with water
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-16c176a13bb94f7ca2a729b1a87d8a4c
Source dataset
uspto-grants-1976_05
Patent number
US03956325

Reaction notes

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