HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 54338265, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 68138178 | HCID 68138178 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | HCID 54338265 | HCID 54338265 | — |
Reaction Steps
A mixture of 39 g. of 2-methyl-2-[4-(4-bromophenyl)-phenoxy]-propionic acid diethylamide [obtainable by bromination of 2-methyl-2-(4-phenylphenoxy)-propionic acid diethylamide], 8.5 g. of piperidine, 2.4 g. of NaH, and 60 ml. of HMPA is agitated overnight at 150°. After cooling and the usual working-up operation, 2-methyl-2-[4-(4-piperidinophenyl)-phenoxy]-propionic acid diethylamide is obtained, m.p. 100°-102°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03956334 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-78b1c00020fc4d89b89a4ac7b09eaa68 |
| Source note | uspto-grants-1976_05 |