HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Chlorophenoxymethyl)oxirane → 1-[3-(o-Chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Chlorophenoxymethyl)oxirane | HCID 137500 | — |
| Reactant | 1-(Piperidin-4-yl)-1,3-diazinan-2-one | HCID 15572666 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[3-(o-Chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine | HCID 20368054 | — |
Reaction Steps
A solution of 9.2 g of 1-(o-chloro-phenoxy)-2,3-epoxypropane and 9.15 g of 1-(4-piperidyl)-2-oxo-hexahydro-pyrimidine in 7 ml of abs. ethanol is heated for 5 hours to 95°C and then evaporated in vacuo. The residue is recrystallised from chloroform/petroleum ether to yield the 1-[3-(o-chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine, which melts at 150°-153°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03956335 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-67fa100aec1547f3b1208117394a2103 |
| Source note | uspto-grants-1976_05 |