Sulfuric Acid → HCID 21539679, compound

Participants

Reaction Conditions

Reaction Steps

Five ml. of concentrated sulfuric acid was cooled to 0°C. in an ice bath and added directly to 0.5 g. of 3-(3-pyridyl)-5-isoxazoleethanol. The reaction was allowed to stir 1/2 hour at 0°C. and then was poured over 50 g. of ice. The resulting solution was made basic with 5N NaOH, and was extracted with CHCl3. The organic layer was dried over sodium sulfate. Removal of the solvent resulted in a white oil which crystallized on standing, m.p. 60°-64°C.

Provenance & Evidence