3-Ethyl-4-methylpyridine → HCID 178437070, compound

HRID 1076273Notes

Reaction equation

HRID 1076273 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[C:13](Br)=[C:12]([NH:17][C:18](=[O:46])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([NH:25][C:26](=[O:45])[CH2:27][O:28][C:29]3[CH:34]=[CH:33][C:32]([C:35]([CH2:38][CH3:39])([CH3:37])[CH3:36])=[CH:31][C:30]=3[C:40]([CH2:43][CH3:44])([CH3:42])[CH3:41])[CH:20]=2)[NH:11]1.[CH3:47][CH2:48][C:49]1[CH:54]=[N:53][CH:52]=[CH:51][C:50]=1[CH3:55]>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[C-:13]([N+:53]2[CH:52]=[CH:51][C:50]([CH3:55])=[C:49]([CH2:48][CH3:47])[CH:54]=2)[C:12]([NH:17][C:18](=[O:46])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([NH:25][C:26](=[O:45])[CH2:27][O:28][C:29]3[CH:34]=[CH:33][C:32]([C:35]([CH2:38][CH3:39])([CH3:37])[CH3:36])=[CH:31][C:30]=3[C:40]([CH2:43][CH3:44])([CH3:42])[CH3:41])[CH:20]=2)=[N:11]1

Participants

4

Reactant 2

HCID 682543-Ethyl-4-methylpyridineHCID 20356574HCID 20356574, compound

Product 1

HCID 178437070HCID 178437070, compoundYield 94.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 g Of 1-(2,4,6-trichlorophenyl)-3-{3-[(2,4-di-tert-amylphenoxy)acetamido]benzamido]-4-bromo-5-pyrazolone and 6.4 g of β-collidine were refluxed in 100 ml of ethanol for 5 hours. After cooling, the resulting crystals were washed with water and dried, and recrystallized from ethanol to give 10 g of Compound 3 having a melting point of 162° to 165°C.

Workup

  1. temperatureAfter cooling
  2. washthe resulting crystals were washed with water
  3. customdried
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-a4f3494b9d674e0f9030803f8a6f479c
Source dataset
uspto-grants-1976_05
Patent number
US03956339

Reaction notes

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