Iodine → HCID 178443173, compound

Participants

Reaction Steps

A mixture of 7.1 g of 1-(2,4,6-trichlorophenyl)-3-[2-chloro-5-(n-tetradecanamido)anilino]-5-pyrazolone, 2.5 g of iodine and 100 ml of pyridine was heated on a steam bath for 5 hours. After cooling, the reaction mixture was poured into a large volume of ice water. The precipitate was collected by filtration and dried. The powder was recrystallized from a solvent mixture of hexane and ethyl acetate to give 4.8 g of Compound 18 as yellow crystals having a melting point of 124° to 128°C.

Provenance & Evidence