4-Chlorobenzaldehyde → 1-(p-Chlorophenyl)-4-phenyl-7-(m-chlorophenyl)-1,6-heptadien-3-one

Participants

Reaction Steps

A sodium hydroxide solution (7.5 ml., 20%) is added to a solution of p-chlorobenzaldehyde (17.86 g., 0.127 mole) and 3-phenyl-6-(m-chlorophenyl)-5-hexen-2-one (36.11 g., 0.127 mole) in ethanol (360 ml.) with stirring. The gum that separates on continued stirring is chromatographed (benzene) through a silica gel column to obtain the product as a very viscous oil (opaque).

Provenance & Evidence